期刊论文

中文

中国处方药

1671-945X

2023

21

12

49-53

10.3969/j.issn.1671-945X.2023.12.012

2021JJ30418:湖南省自然科学基金项目 21C0248:湖南省教育厅项目

本校为第一机构

目的 通过网络药理学探讨阳和汤治疗三阴性乳腺癌的作用机制.方法 通过TCMSP数据库筛选出阳和汤的药物主要活性成分及其靶点;通过GeneCards数据库筛选三阴性乳腺癌的潜在靶点;采用Cytoscape 3.7.2 软件构建"药物-活性成分-靶基因-疾病"网络图;将整合后的阳和汤治疗三阴性乳腺癌的靶点导入STRING数据库构建蛋白质-蛋白质相互作用网络图,并通过R语言软件对关键靶点进行GO和KEGG富集分析.结果 阳和汤治疗三阴性乳腺癌的主要活性成分有槲皮素、木樨草素、谷氨酸、油酸等.阳和汤的靶标基因与三阴性乳腺癌的靶标基因交集靶基因 172 个,如HIF-1α、EGFR、BCL2、VEGFA、IL-6、HK2 等.GO功能富集分析得到...

Objective To explore the mechanism of Yanghe Decoction in the treatment of triple negative breast cancer through network pharmacology.Methods The main active components and their targets of Yanghe Decoction were screened by TCMSP database;Potential targets of triple negative breast cancer were screened through GeneCards database;The network diagram of"drug active ingredient target gene disease"was constructed by using Cytoscape 3.7.2 software;The integrated targets of Yanghe Decoction for triple negative breast cancer were imported into STRING ...