期刊论文

EFFECTS OF ACUPUNCTURE ON APOPTOSIS AND EXPRESSION OF ENDOTHELIAL CELLS IN RABBITIS WITH ARTERY RESTRUCTURE

中文

中国中医药科技

1005-7072

2008

15

1

3-5

10.3969/j.issn.1005-7072.2008.01.002

国家自然科学基金资助项目No.30371809

本校为第一机构

目的:观察针刺对家兔实验性动脉再狭窄的防治作用并探讨其作用机理.方法:应用PTCA球囊导管对实验兔行双侧髂动脉内膜剥脱以建立动脉粥样硬化模型,术后1月髂动脉造影示50%以上狭窄者再行PICA球囊扩张术,以建立再狭窄模型.模型成功后,将造模动物随机分成针刺实验组、普罗布考组、模型组,每组8只.自术前2天至术后14天为1疗程,针刺内关(双)、厥阴俞(双)、心俞(双)、膻中、足三里(双)等穴.髂动脉取材,石蜡切片,TUNEL.染色,DAB 柚显色,苏木素复染.观察各组动脉内皮细胞凋亡率及Bax、Bcl-2基因蛋白表达.结果:针刺组内皮细胞凋亡率及Bax 基因表达明显高于模型组(P＜0.01),针刺后Bax/Bcl-2比值明显升高.结...

Objective:To observe the effects of acupuncture in preventing and treating artery restructure of rabbits. Methods:Artery restructure models were established by PTCA sacculus proprius to denudation arteria inner membrane two sides.Rabbits were divided into four groups:normal,model,acupuncture and probucol groups.It was a treatment course from the first 2 days preoperation to the 14th day post operation.Acupuncturing aoupoints such as neiguan,jueyinshu,xinshu,tanzhong and zusanli,etc.were taken.The rate of apoptosis in arterial endothelial cells and the expression of Bax and Bcl-2 genes protein ...