18-GA-Suc Modified Liposome Loading Cantharidin for Augmenting Hepatic Specificity: Preparation, Characterization, Antitumor Effects, and Liver-Targeting Efficiency

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhu, Kun;Zhou, Lili;Zou, Manshu;Ning, Shuangcheng;Liu, Shulan;...

通讯作者：

Zhang, Xiaoqing;Xia, XH

作者机构：

[Xia, Xinhua; Du, Ke; Zhang, Xiaoqing; Zhou, Lili; Zou, Manshu; Ning, Shuangcheng; Xia, XH; Zhu, Kun; Liu, Shulan; Zhou, Yilin] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R China.

通讯机构：

[Zhang, XQ; Xia, XH ] H

Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R China.

语种：

英文

关键词：

3 succinyl 30 stearyl glycyrrhetinic acid;cantharidin;drug carrier;liposome;unclassified drug;cantharidin;animal experiment;antineoplastic activity;apoptosis;area under the curve;Article;cancer inhibition;cell cycle;chemical modification;controlled study;drug distribution;drug half life;drug release;drug synthesis;drug targeting;IC50;in vitro study;in vivo study;liver cell carcinoma;nonhuman;rat;Hep-G2 cell line;human;liver tumor;tissue distribution;Cantharidin;Hep G2 Cells;Humans;Liposomes;Liver Neoplasms;Tissue Distribution

期刊：

Journal of Pharmaceutical Sciences

ISSN：

0022-3549

年：

2020

卷：

109

期：

页码：

2038-2047

DOI：

10.1016/j.xphs.2020.03.001

基金类别：

This work was supported by the Natural Science Foundation of China (No. 81573621), the Natural Science Foundation of Hunan Province of China (No. 2019JJ50438) and the Scientific Research Fund of Hunan Provincial Education Department (No. 15A141).

机构署名：

本校为第一且通讯机构

院系归属：

药学院

摘要：

Cantharidin (CTD), a natural Chinese medicine constituent extracted from mylabris, is a potent drug against hepatocellular carcinoma. However, the clinical application of CTD was limited because of its toxicity and low solubility. In this work, a novel CTD-loaded liposome modified with 3-succinyl-30-stearyl glycyrrhetinic acid (18-GA-Suc-CTD-Lip) was prepared to enhance liver-targeting efficiency and antitumor activity. 18-GA-Suc-CTD-Lip and CTD-Lip were successfully prepared by film dispersion method and totally characterized. The antitumor ef...

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18-GA-Suc Modified Liposome Loading Cantharidin for Augmenting Hepatic Specificity: Preparation, Characterization, Antitumor Effects, and Liver-Targeting Efficiency

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