A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats

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成果类型：

期刊论文

作者：

Meng, Pan;Zhang, Xi;Liu, Tong-tong;Liu, Jian;Luo, Yan;...

通讯作者：

Wang, YH;Ge, JW

作者机构：

[Meng, Pan; Xie, Ming-xia; Luo, Yan; Wang, Yu-hong; Liu, Tong-tong; Zhong, Zi-yan] Hunan Univ Chinese Med, 300 Xueshi Rd, Hanpu Sci & Educ Pk, Changsha, Hunan, Peoples R China.

[Zhang, Xi; Guo, Dong-wei] Second Peoples Hosp Hunan Prov, Changsha, Hunan, Peoples R China.

[Yang, Hui; Liu, Jian] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha, Hunan, Peoples R China.

[Fang, Rui; Ge, Jin-Wen] Hunan Acad Chinese Med, 58 Lushan Rd, Changsha, Hunan, Peoples R China.

通讯机构：

[Wang, YH ; Ge, JW ] H

Hunan Univ Chinese Med, 300 Xueshi Rd, Hanpu Sci & Educ Pk, Changsha, Hunan, Peoples R China.

Hunan Acad Chinese Med, 58 Lushan Rd, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Xiaoyaosan;Depression;Whole transcriptomic analysis;Synapse loss;BDNF/trkB/PI3K signal axis

期刊：

BMC Complementary Medicine and Therapies

ISSN：

2662-7671

年：

2023

卷：

期：

页码：

1-19

DOI：

10.1186/s12906-023-04000-0

基金类别：

This work was funded by grants from the National Natural Science Foundation of China (No.81403387), Outstanding youth project of Natural Science Foundation of Hunan Province(No. 2020JJ3027), Excellent postdoctoral innovative talents of Hunan Province (No. 2020RC2060), the training plan of outstanding innovative youth of Changsha(No. kq2009018).

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

摘要：

BACKGROUND: Depression is a neuropsychiatric disease resulting from deteriorations of molecular networks and synaptic injury induced by stress. Traditional Chinese formula Xiaoyaosan (XYS) exert antidepressant effect, which was demonstrated by a great many of clinicalandbasicinvestigation. However, the exact mechanism of XYS has not yet been fully elucidated. METHODS: In this study, chronic unpredictable mild stress (CUMS) rats were used as a model of depression. Behavioral test and HE staining were used to detect the anti-depressant effects of XYS. Furthermore, whole transcriptome sequencing ...

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A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats

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