期刊论文

Zeng, PH

英文

Journal of Translational Medicine

1479-5876

2025

23

1

1-16

10.1186/s12967-025-06301-z

This study was supported by National Natural Science Foundation of China (82074425), Natural Science Foundation of Hunan Provincial(2023JJ30364 and 2023JJ30361), Key Research and Development Program of Hunan Provincial (2023SK2057), Key Project of Hunan Provincial Administration of Traditional Chinese Medicine (A2023042), Graduate Research Innovation Program of Hunan Provincial(CX20230835), Health and Wellness Research Program of Hunan Provincial(20232605), Major Scientific Research Project for High-Level Talent of Hunan Provincial(R2023081); Clinical Research Center for the Prevention and Control of Cancer Integrating Traditional Chinese and Western Medicine (Hunan Traditional Chinese Medicine Letter [2022] No. 93), Traditional Chinese Medicine Shennong Leading Talent Program of the Hunan Provincial Health Commission, and Hunan Provincial High-Tech Talent Program of the Hunan Provincial Science and Technology Department. We gratefully acknowledge the financial support which made this research possible.

本校为通讯机构

Lung cancer, one of the leading causes of cancer-related morbidity and mortality worldwide, is strongly associated with smoking as its primary carcinogenic factor. However, despite the strong link between smoking and lung cancer, not all smokers develop the disease, suggesting that individual genetic susceptibility and molecular mechanisms may play a critical role in the onset of lung cancer. Understanding the gene-driving mechanisms and immune regulatory pathways involved in smoking-related lung cancer remains one of the key challenges in current lung cancer research. This study employs an in...