期刊论文

中文

中国中西医结合耳鼻咽喉科杂志

1007-4856

2007

15

3

166-170

10.16542/j.cnki.issn.1007-4856.2007.03.003

河南中医学院科研苗圃工程项目（编号2005MP007）；

本校为其他机构

目的 建立肺气虚-变应性鼻炎病证复合动物模型,观察模型动物血清Th1/Th2细胞因子网络失衡与变应性鼻炎肺气虚证的相关性.方法 采用烟熏法及TDI鼻腔激发法,建立豚鼠肺气虚-变应性鼻炎病证复合模型,运用双抗体夹心ELISA法检测致敏豚鼠血清IFN-γ和IL-4水平,分析细胞因子水平变化与模型动物病理变化的相关性.结果 肺气虚型变应性鼻炎豚鼠血清IL-4升高,IFN-γ下降,IFN-γ/IL-4比值降低,与正常对照组比较差异具有统计学意义（P＜0.01）.结论 变应性鼻炎及肺气虚证的发生均与Th1/Th2细胞因子网络失衡有关,由Th2反应为主的变应性炎症构成了变应性鼻炎鼻腔黏膜的病理特征.

Objective To explore the association of imbalanced serum Th1/Th2 cytokine network with the development of allergic rhinitis in the pattern of Lung Qi deficiency based on the establishment of a model combined disease and TCM pattern induced among guinea pigs. Methods The combined disease and pattern model was prepared by means of the procedures through smoke inhaling and TDI dropping into the nose among the experimental animals. Then, ELISA procedures were utilized to determine the serum levels of IL-4 and IFN-γ in these models, and an analysis...