期刊论文

EFFECTS OF EACH AVAILABLE COMPOSITION AND THE COMBINATION OF BUYANGHUANWU DECOCTION ON CEREBRAL ISCHEMIA IN MICE

中文

湖南中医药大学学报

1674-070X

1999

19

4

1-3

10.3969/j.issn.1674-070X.1999.04.001

国家自然科学基金!（编号39770893）；

本校为第一机构

为研究补阳还五汤抗脑缺血的有效成分部位及其配伍关系，从补阳还五汤中提取了７ 类有效成分部位，采用小鼠双侧颈总动脉和迷走神经结扎法造成脑缺血模型，研究各有效成分部位的作用，以正交实验法分析各有效成分部位的交互作用及有效剂量组合。结果：总生物碱、总多糖、总甙、总甙元和挥发油单独应用均可使小鼠耐缺血时间明显延长，而蛋白质和氨基酸单独应用无明显作用；正交实验表明，蛋白质、氨基酸与其它有效部位之间以及两者之间均无交互作用；三水平正交实验表明，在配伍上，各有效成分部位应取的有效剂量组合为：生物碱为生药０．５８ ｇ／ｋｇ 体重，多糖为生药１１．４４ ｇ／ｋｇ 体重...

Object:Available compositions abstracted from Buyanghuanwu decoction and their compatibilities on antagonisming experimental cerebral ischemia.Method:Seven available compositions were abstracted from Buyanghuanwu decoction. Effects of each available composition on cerebral ischemia in mice induced by ligating bilateral common carotid artery and Vagus were studied.Interaction and the combination of effective dose of each composition were studied with orthogonal test.Result:1)Total alkaloids,Polysaccharides,saponins,aglycones and volatiles applied alone could prolong obviously the time of ischem...