Objective To observe the effect of electro-acupuncturing on Po 2 in tissue of acupoints along Foot-Yangming Meridian in rabbits. Methods We dynamically observed the changes of Po 2 in tissues of three groups of acupoints as Liangmen, Tianshu, Zusanli, and Jiexi of Foot-Yangming Meridian and in tissues of region 1cm away from these points on both sides. Results The tissue Po 2 values immediately after puncturing and that 15 minutes later were significantly decreased(P