期刊论文

中文

湖南中医药大学学报

1674-070X

2003

23

2

4-6

10.3969/j.issn.1674-070X.2003.02.002

国家自然科学基金 （C30 0 0 0 2 2 5 ）； 国家中医药管理局基础研究项目（2 0 0 0 -J-T -17）； 湖南省教委青年项目 （0 1B0 14 ）资助；

本校为第一机构

目的探讨一氧化氮(NO)及肿瘤坏死因子α(TNF-α)在妊娠高血压综合征及胎儿宫内发育迟缓发病中的作用及益气化瘀法提高胎盘血供的内在机制.方法采用L-精氨酸甲酯(L-NAME)于妊娠第10d起皮下注射制作大鼠妊娠高血压综合征模型,黄芪丹参注射液及硝酸甘油干预,于妊娠第18d用亚硝酸根还原酶法检测血浆NO水平,ELISA法检测血浆TNF-α含量.结果模型组NO含量明显降低(P

Objective To explore the effects of NO and tumor necrosis factor α(TNF α) on the develo pment of pre gnant hypertension syndrome(PHS) and fetal intrauterine growth retardation(FIGR) and the machenism of Qi boosting Blood quickening method(QBBQM) to increase p lace ntal blood supply. Methods Rat model was prepared by L Arginin e methyl ester(L NAME) subcutaneously injected to the pregnant animals on the 10th day of pregnacy.Then,Astragalus and Salvia Injection(ASI) and nitroglycer ine were used to cause intervening effect to the modeling anima...