期刊论文

中文

湖南中医药大学学报

1674-070X

2003

23

3

1-4

10.3969/j.issn.1674-070X.2003.03.001

湖南省中青年科技基金资助项目 （ 0 0JZY2 14 5 ）；

本校为第一机构

目的探讨脑泰方提取物预处理减轻沙土鼠脑缺血再灌注损伤的作用.方法采用钳夹双侧颈总动脉建立沙土鼠脑缺血模型,将130只沙土鼠随机分为假手术组(SOG),脑缺血再灌注损伤组(IRG组)、脑缺血预处理组(IPG组)、脑泰方提取物预处理组(NPG组),根据再灌注不同时间(24、48、72 h和7 d).将IRG组、IPG组、NPG组各分4个亚组(n=10).观察各时相沙鼠,海马CA1区存活神经元数目、脑组织含水量以及脑毛细血管通透性.结果①IPG组、NPG组与IRG组同期比较,脑含水量、伊文思蓝含量明显降低(P

?Objective To investigate the preconditional effect of Naotai Formula Extract(NFE) on the cerebral ischemia reperfusion(CIR) injury in gerbils. Methods CIR model was prepared by bilateral carotid occlution with incarceration method in gerbils. Then, 130 animals were randomly divided into sham operation group (SOG), cerebral ischemia reperfusion injury group (IRG), cerebral ischemia preconditioning group (IPG) and NFE preconditioning group (NPG). Furthermore, IRG, IPG and NPG were divided into 4 sub groups respectively based on the reperfusion d...