期刊论文

Effects of Changyanyu tablet on serum IL-2 and NO of ulcerative colitis in rats

中文

湖南中医药大学学报

1674-070X

2007

27

6

18-20

10.3969/j.issn.1674-070X.2007.06.006

国家中医药管理局资助项目（2000076）；

本校为第一机构

目的 观察肠炎愈片对大鼠慢性溃疡性结肠炎血清白介素-2(IL-2)、一氧化氮(NO)的影响.方法 用免疫法建立大鼠慢性溃疡性结肠炎模型,将造模后的大鼠随机分为模型组、肠炎愈片高、中、低剂量组、补脾益肠丸组、柳氮磺吡啶组6组,另设正常对照组,共7组.观察肠道形态和组织学改变,采用ELISA法测定血清中IL-2、检测用药后血清NO的含量.结果 与模型组比较,肠炎愈片各剂量组血清IL-2含量升高(P＜0.05);肠炎愈片高、中剂量组血清NO含量显著低于模型组(P＜0.01).肠炎愈片高、中、低剂量组形态和组织学损伤评分明显下降(P＜0.05).结论 肠炎愈片各剂量组治疗UC的机制可能与其恢复提高IL-2水平,从而使Th1/Th2的...

Objective To observe the effects of Changyanyu tablet on serum IL-2 and NO of ulcerative colitis in rats. Methods All rats, induced the ulcerative colitis models by immunological method, were divided into seven groups： normal group, high, middle and low doses of Changyanyu tablet （7.92,3.96,1.98 g/kg·d）groups, Bupi Yiehang pill group and SASP group. The maeroseopieal and histological changes of the colon were evaluated; and IL-2 and NO were detected with ELISA. Results Compared with model group, IL-2 in the 7.92 g/kg,3.96 g/kg and 1.98 g/kg...