期刊论文

中文

湖南中医药大学学报

1674-070X

2007

27

2

15-16+19

10.3969/j.issn.1674-070X.2007.02.006

国家自然科学基金项目（30271678,30572408）； 国家中医药管理局基金项目（02-03JP29）；

本校为第一机构

目的 观察益气解毒方对小鼠力竭游泳所致气虚体质状态下自由基代谢的影响.方法 将48只昆明种小鼠随机分为正常对照组(HCG),模型组(MG),益气解毒方组(TG),维生素C阳性对照组(PCG).HCG常规饲养,其余3组采用控食[150 g/(kg.d)]加力竭游泳造成气虚体质状态;TG和PCG造模同时用益气解毒方[生药20 g/(kg.d)]和维生素C(90.8 mg)灌胃,HCG和MG灌服生理盐水.实验第16天,观察小鼠负重游泳时间,并检测血清、鼻咽和肝组织中自由基代谢相关指标MDA、SOD和GSH-Px.结果 MG与HCG比较,力竭游泳时间明显缩短(P＜0.01);TG与MG比较,力竭游泳时间显著延长(P＜0.01);HCG和PCG比较差异无统计学意义;在血清、鼻咽和肝组织中...

Objective To investigate the effect of Yiqi Jiedu Decoction（YJD） on free radical metablism in mice with Qi deficient constitutional status induced by exhaustive swimming. Methods Forty-eight mice were randomly divided into 4 groups, i.e. treating group （TG）, positive control group （PCG）, model group （MG） and healthy control group （HCG）, 12 mice each group. All the mice in TG, PCG and HCG were given the food controlled the amount of 150 g kg-l.d-1 with exhaustive swimming exercise to be in a Qi deficienct status, the mice in HCG were k...