期刊论文

中文

湖南中医药大学学报

1674-070X

2009

29

3

30-32

10.3969/j.issn.1674-070X.2009.03.010

[基金项目]湖南省科技厅基金资助项目（04SK1007-13）.

本校为第一机构

目的 建立阿尔茨海默病(AD)的大鼠模型,并观察远志总皂苷对AD模型大鼠学习记忆及胆碱能系统的影响.方法 将70只大鼠随机分为模型组,远志总皂苷高、中、低剂量组,盐酸多奈哌齐组,正常组和假手术组共7组,每组10只.采用双侧海马内一次性注射β-淀粉样多肤25-35片断(Aβ25-35)制作大鼠AD模型;连续给药5周后采用水迷宫检测各组大鼠的学习记忆能力:采用生化法检测各组大鼠脑组织匀浆中乙酰胆碱酯酶(AchE)、胆碱乙酰转移酶(CHAT)活性变化.结果 与模型组相比,远志总皂苷干预治疗组大鼠进入盲端的次数明显减少、游泳时间明显缩短,同时脑内ChAT活性增强,AchE活性降低,差异均具有统计学意义(P

[Abstract~ Objective To establish an animal model of Alzheimer＇s disease （AD） and ob- serve the therapeutic effect of saponins of polygala on learning and memory and aetivities of AchE and CHAT. Method The 70 rats were randomly divided into seven group as following： model group, saponins of polygala groups respectively at high, moderate and low doses, Donepezil Hydroehloride tablets group, sham-operation group and normal group. The amyloid-β25-35 was injected into the hippocampus to induce learning and memory dysfunctions in rats, after 5 ...