期刊论文

中文

湖南中医药大学学报

1674-070X

2009

29

2

40-42

10.3969/j.issn.1674-070X.2009.02.014

湖南省教育厅重点科研资助项目（05A032）；

本校为第一机构

目的 研究九香止泻片素片最佳成型工艺条件,为该制剂包肠溶衣奠定基础.方法 通过单因素重复试验,考察了黏合剂的种类、稀释剂和崩解剂的配比、崩解剂的加入方法 及压片机压力对本制剂成型性能的影响.结果 最优工艺条件:干浸膏粉:乳糖:微晶纤维素(内、外各加4%)的配比为100:18:8,5%PVPk3095%乙醇浪为黏合剂,0.5%硬脂酸镁为润滑剂,压片机压力为9.5 kg.结论 按此工艺参数制粒、压片,素片成型性能最佳,质量符合规定和包肠溶衣的要求.

Objective To research the optimal formation process of Jiuxiang Zhixie enteric- coated compressed tablets. Methods through the repeated experiment with signal factor, the varieties of adhesives, the proportion of diluents and disintegrants, the adding methods of disintegrants, and the pressure of the tablet press were investigated. Results The best optimal process conditions were 5% PVPr,30 95%EtOH, 18%lactose, 8%MCC, 0.5% magnesium lubricant and 9.5 kg pressure of the tablet press. Conclusion The conditions are the most rational f...