期刊论文

Effection of Ireris sonchifolia on hemorheology and biochemical indicators in focal cerebral ischemia rats

中文

湖南中医药大学学报

1674-070X

2009

29

2

32-33+54

10.3969/j.issn.1674-070X.2009.02.011

湖南科技厅科研基金资助项目（2008115）.

本校为第一机构

目的 探讨苦碟子对局灶性脑缺血大鼠血液流变学及生化指标的影响.方法 阻断大鼠一侧大脑中动脉建立局灶性脑缺血模型,观察苦碟子对大鼠血液流变性、超氧化物歧化酶(SOD)、丙二醛(MDA)、血栓素B2(TXB2)、6-酮-前列腺素F1a(6-Keto-PGF1a)等指标的影响.结果 苦碟子高剂量组能明显降低大鼠血液黏度,提高SOD活性,降低MDA含量,与模型组相比差异具有统计学意义(P＜0.01);同时能降低TXB2含量及升高6-Keto-PGF1a含量,与模型组相比差异有统计学意义(P＜0.05).结论 苦碟子能改善模型大鼠血液流变学及生化指标,具有抗局灶性脑缺血的作用.

Objective To investigate the influence of Ireris sonchifolia on hemorheology and biochemical indicators in focal cerebral ischemia rats. Method Focal cerebral ischemia models were induced by blocking one side of the middle cerebral artery; the effect of Ireris sonchifolia on the indicators of hemorheology, SOD, MDA, TXB2 and 6-Keto-PGF1, were ob- served. Results Compared with the model group, the blood viscosity was significantly reduced, the activity of SOD increased, and the content of MDA reduced in the high dosage group of Ireris sonchifoli...