期刊论文

中文

湖南中医药大学学报

1674-070X

2010

30

7

22-24

10.3969/j.issn.1674-070X.2010.07.007.022.03

本校为第一机构

目的 探讨丹参注射液联合卡托普利对大鼠肺纤维化的治疗作用及可能的机制.方法 将24只清洁级雄性SD大鼠随机分为正常组、模型组、卡托普利联合丹参注射液组(治疗组),每组8只.模型组和治疗组采用博莱霉素造模,造模后10 d处死所有大鼠,均采用HE染色行肺泡炎、肺纤维化程度分级,并测定大鼠血浆起氧化物歧化酶(SOD)、丙二醛(MDA)含量.结果 与正常组比较,造模组大鼠肺泡炎及肺纤维化评分、MDA含量均明显升高,差异具有统计学意义(P＜0.05,P＜0.01),SOD含量均降低差异有统计学意义(P＜0.01);与模型组比较,治疗组大鼠肺泡炎及肺纤维化评分、MDA含量均明显降低,差异有统计学意义(P＜0.05,P＜0.01),SOD含量...

Objective To observe the effect and mechanism of captopril combined salvia injection on the pulmonary fibrosis in rats. Methods 24 male SD rats were randomly divided into norreal control group. model group and captopril combined salvia injection group（treatment group）, 8 rats per group. The rats in model and treatment groups were modeled with bleomycin, then killed all rats after 10 days, the alveolitis and pulmonary fibrosis were graded with HE staining, and the contents of SOD and MDA were detected. Results Compared with control group, the ...