期刊论文

Effect of Naodejian decoction on nerve function and infarct volume in rats after focal cerebral ischemia

中文

湖南中医药大学学报

1674-070X

2010

30

1

9-11

10.3969/j.issn.1674-070X.2010.01.004

30300470.30472217,30873355:国家自然科学基金 20060541007:高等学校博士学科点专项科研基金 209087;08A049:教育部人文社会科学研究项目

本校为第一机构

目的 探讨脑得健方对大鼠局灶性脑缺血后神经功能及脑梗死面积比的影响.方法 将大鼠随机分为假手术组、模型组、补阳还五汤组、脑得健方高、中、低剂量组,每组20只.大脑中动脉线栓法复制局灶性脑缺血模型,于手术后3 d和7 d评价其神经功能,每组随机取5只做ITC并计算梗死面积比,5只计算大脑干湿重比.结果 脑缺血后模型大鼠有神经功能障碍、出现大面积梗死和组织水肿,治疗7 d后,脑得健方各剂量和补阳还五汤均能改善模型大鼠的神经功能缺失症状,减小梗死面积,减轻脑组织水肿,分别与模型组比较,差异均具有统计学意义(P

Objective To explore the effect of Naodejian decoction on nerve function and infarct volume in rats after focal cerebral ischemia. Methods Rats were randomly divided into the shame, ischemic, ischemic with Buyang Huanwu decoction（BHD）, ischemic with Naodejian decoction （ND） high-dose, ischemic with ND medium-dose, ischemic with ND low-dose groups, 10 rats per group. The model was reproduced by occluded middle cerebral artery. The neurological function were evaluated after surgery before the execution, 5 rats were random from each group to c...