期刊论文

中文

湖南中医药大学学报

1674-070X

2010

30

7

12-15

10.3969/j.issn.1674-070X.2010.07.004.012.04

湖南省自然科学基金项目资助（08JJ5001）； 湖南省教育厅重点科研课题（06A051）；

本校为第一机构

目的 观察愈(癎)灵颗粒对戊四氮(PTZ)致(癎)大鼠海马纤维出芽(MFS)的影响.方法 选取70只清洁级SD大鼠,从中随机选取10只作为空白对照组.其余动物用戊四氮(PTZ)造模,将符合模型标准的大鼠随机分为3组,即愈(癎)灵颗粒组、丙戊酸钠组和模型组.运用Timm染色法观察MFS,探讨愈(癎)灵颗粒对海马MFS的影响.结果 模型组与空白组比较,大鼠海马IML出芽目测评级差异无统计学意义(P＞0.05),海马CA3区神经出芽的黑染点数目和面密度、平均光密度和积分光密度结果比较差异均有统计学意义(P＜0.05),综合常规切片结果提示癫(癎)可导致海马神经元死亡,进而导致纤维出芽.愈(癎)灵颗粒组与模型组比较,愈(癎)灵颗粒可降...

Objective To observe the effect of Yuxianling granule（YXLG） on the MFS in epileptic model rats caused by PTZ.Methods 70 SD rats,except for 10 rats were selected randomly as the blank control group,were modeled by pentylenetetrazol（PTZ） and divided randomly into three groups,YXLG group,sodium valproate group and model group.MFS was observed with Timm and the effect of YXLG on MFS was studied.Results Compared the model group,the difference of with blank group,the MFS of IML was not significant（P0.05） and the differences of the dyed-black po...