期刊论文

中文

湖南中医药大学学报

1674-070X

2010

30

3

12-13,47

10.3969/j.issn.1674-070X.2010.03.004.012.02

湖南省自然科学基金项目（06JJ4038）； 湖南省教育厅科研基金资助项目（07c496）；

本校为第一机构

目的 观察灭幽汤对昆明小鼠幽门螺杆菌(H.Pylori)相关性胃炎的疗效及其对NF-κB表达的影响.方法 采用H.pylori菌液灌胃法造模,将造模成功的小鼠按体质量随机分为模型组、灭幽汤高、低剂量组、三九胃泰组,连续给药2用.HE染色观察胃组织病理形态学改变,免疫组化法分析NF-κB蛋白的表达.结果 灭幽汤高、低剂量组H.Pylori阳性率均明显低于模型组及三九胃泰组,差异有统计学意义(P

Objective To observe the effects of Mieyou decoction on NF-κB expression and the curative effect of it for H.p-associated gastritis.Methods After the modeling,induced with lavaging H.p bacilli,all the mice were randomly divided into model group,Miey-ou decoction high,middle and lower dosages group,Sanjiu Weitai group.After 2 weeks of ad-ministration,the changes of gastric tissues were measured with HE staining,and NF-κB pro-tein expression with immunohistochemistry analysis.Results The H.p positive rate in Miey-ou decoction groups were lower ...