期刊论文

Effects of JZTX-V on withdrawl symptoms in morphine dependent mice

中文

湖南中医药大学学报

1674-070X

2011

31

7

11-13

10.3969/j.issn.1674-070X.2011.07.003.011.03

2009CB5265 10.2010CB529800:国家重点基础研究发展计划（973计划） 2006AA02Z141:国家高技术研究发展计划（863计划） 07JJ3072:湖南省自然科学基金 NCET-07-0279;OTA035:新世纪优秀人才支持计划

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目的 观察Jingzhaotoxin-V敬钊毒素-V(JZTX-V)对纳洛酮催促戒断症状的治疗作用.方法 建立吗啡成瘾小鼠模型,分别测定4组不同剂量5,50,500,1000μg/kg JZTX-V对小鼠戒断后跳跃次数的影响.结果 JZTX-V在戒断后的15min内能减少小鼠的跳跃次数,而且5、50和500 μg/kg JZTX-V对跳跃次数的抑制具有统计学意义(P＜0.05、P＜0.01).结论 JZTX-V在5-500μg/kg范围内能显著抑制小鼠戒断后的跳跃次数,有可能成为一种戒毒先导分子.

Objective To observe the treatment effects of Jingzhaotoxin-V（JZTX-V） on withdrawl symptoms aroused by Naloxone precipitation.Methods The mice models with morphine addiction were divided in 5,50,500 and 1000 μg/kg JZTX-V groups and each dose affected on the jumping times of mice after withdrawl.Results The JZTX-V reduced the jumping times of mice during the 15 minutes after withdrawl,and the doses 5,50 and 500 μg/kg JZTX-V were significant to inhibit the jumping times（P0.05 and P0.01）.Conclusion When the doses between 5 and 500 μg/kg,JZT...