期刊论文

中文

湖南中医药大学学报

1674-070X

2011

31

1

22-24

10.3969/j.issn.1674-070X.2011.01.006.022.03

08B057:湖南省教育厅科学研究青年项目 CX2009B173:湖南省研究生科研创新项目

本校为其他机构

目的 研究雄性"肾阳虚"亚健康大鼠模型,为调理男性肾阳虚亚健康找寻科学配方.方法 控制用药剂量及灌胃时间,用维生素B4建立雄性"肾阳虚"亚健康大鼠模型,检测腺垂体-睾丸轴激素、氧化损伤因子及抗氧化损伤因子、睾丸组织微细结构作为判断亚健康组织学依据.结果 与正常大鼠相比较,模型大鼠血清FSH、LH、T均降低,均有统计学意义;模型大鼠血清SOD下降,差异有统计学意义(P＜0.05);MDA增加,差异有统计学意义(P＜0.01);模型大鼠睾丸组织曲细精管规则,管腔变大,精子尾部有融合现象,生精细胞层次减少,排列较紊乱,出现空泡现象.结论 运用维生素B4建立的雄性"肾阳虚"亚健康大鼠模型成功.

Objective To explore the sub-health model of male Kidney-yang deficiency in rats and look for a method for regulation of male Kidney-yang deficiency in human.Method Vitamin B4 was used to set up the sub-health rats model of male Kidney-yang deficiency,the level of anterior pituitary-testiculus axle hormone,the content of oxidative damage factors and anti-oxidative damage factors,the fine structure of testicle tissue were detected to measure histological baseness in sub-health condition.Result Compared with normal rats,the levels of FSH,LH,T and...