期刊论文

The effects of Leifengning Decoction on IL-1 and TNF-a levels of rats with adjuvant-induced arthritis

中文

湖南中医药大学学报

1674-070X

2011

31

12

10-12

10.3969/j.issn.1674-070X.2011.12.004.010.03

湖南省自然科学基金资助项目（07JJ5044）；

本校为第一机构

目的 观察类风宁汤对大鼠佐剂性关节炎病理形态学及肿瘤坏死因子-a (INF-a)、白细胞介素-1(IL-1)的影响.方法 将50只大鼠按照随机分组表分为正常组、模型组、类风宁低、高剂量组和阳性对照组.除正常组外,其他各组采用完全弗氏佐剂造模后,观察类风宁汤剂对大鼠佐剂性关节炎大鼠足关节病理形态改变和INF-a、IL-1的影响.结果 类风宁汤能显著抑制佐剂性关节炎模型大鼠足跖滑膜、骨和软骨组织的破坏；与模型组比较,类风宁治疗组大鼠样本中INF-a、IL-1表达的灰度值(Grey)明显升高,光密度值(Density)明显降低,差异具有统计学意义(P＜o.05).结论 类风宁汤对类风湿性关节炎具有一定的治疗作用,能够降低大...

Objective To observe the effects of Leifengning Decoction on pathomorphological changes and levels of IL-1 and TNF-a of rats with adjuvant-induced arthritis.Methods 40 rats were randomly divided into blank control group, model group,treatment group with low dose Leifengning Decoction,treatment group with high dose Leifengning Decoction and positive control group.Except the blank control group,other groups were set as complete Freund＇s adjuvant arthritis models to observe the effects of Leifengning Decoction on pathomorphological changes and le...