期刊论文

中文

湖南中医药大学学报

1674-070X

2011

31

7

18-21

10.3969/j.issn.1674-070X.2011.07.005.018.04

湖南省自然科学基金资助项目（09jj6050）；

本校为第一机构

目的 探讨伤速康贴膏对兔膝骨性关节炎模型关节液中IL-1、IL-6及TNF-α水平的影响.方法 选用日本大耳白兔30只随机分成模型组（A组）、伤速康贴膏组（B组）及骨通贴膏组（C组）,B、C组采用改良Hulth造模法5周后成功复制出兔膝骨性关节炎模型,A组不做任何治疗,B、C组分别予伤速康贴膏和骨通贴膏右膝关节外敷4周,并于用药后第2周、4周2个时相点行右膝关节DR摄影并测定关节液中IL-1、IL-6及TNF-α含量.结果 2个时相点右膝关节DR摄影示B、C组关节退行性改变较A组轻.3组关节液中均可检测到IL-1、IL-6及TNF-α,B、C组在2个时相点含量均低于A组,差异有显著统计学意义(P＜0.01),B、C组在2个时相点均无统...

Objective To explore the effects of Shangsukang emplastrum on IL-1,IL-6 and TNR-α levels in synovia fluid of knee osteoarthritis in rabbits.Methods 30 Japanese white rabbits were randomly divided into model group（Ga）,Shangsukang group（Gb） and Gutong group（Gc）.The rabbits in Gb and Gc were established the model by ameliorated Hulth＇s method and the models were reformed 5 weeks later,and then,they were treated by Shangsukang emplastrum and Gutong emplastrum in 4 weeks,and in Ga they were not be treated.At the 2nd and the 4th week,the radi...