期刊论文

中文

湖南中医药大学学报

1674-070X

2012

32

10

52-54

10.3969/j.issn.1674-070X.2012.10.024.052.03

(RKXH1108):湖南省人口和计划生育委员会项目

本校为第一机构

目的 宫腔注入丹参注射液防治中重度IUA,观察αv β 3、PDGF及TIMP-1在治疗前后宫内膜的表达变化,探讨其与IUA的关系,进一步阐明丹参注射液防治IUA的作用机理.方法 将90例中重度IUA患者随机分为丹参组、欣可聆组及空白组,每组30例,采用双向电泳方法,观察治疗前后αv β 3、PDGF及TIMP-1的表达情况.结果 治疗前3组αvβ 3、PDGF及TIMP-1的表达水平比较差别无统计学意义(P＞0.05),治疗后丹参组及欣可聆组宫内膜PDGF及TIMP-1表达水平低于空白组(P＜0.05),而αv β 3的表达高于空白组(P＜0.05),丹参组及欣可聆组比较差别无统计学意义(P＞0.05).结论 αvβ3、PDGF及TIMP-1的异常表达导致子宫纤维增殖...

Objective To observe the changengs of αvβ3,PDGF and TIMP-1 before and after therapy,by infusing danshen injection into uterine cavity,through such a way to investigate the relationship between danshen injection and IUA,and to elucidate the mechanism of this medicine in preventing and treating IUA.Methods 90 patients were randomly divided into danshen group,viscoelastic solution group and blank control group,30 patients in each group.Observing the changes of αvβ3,PDGF and TIMP-1 before and after therapy,through two-dimensional electrophoresi...