Objective To observe the therapeutic effects and security of kidney-reinforcing and liver-regulating formula in treating breast cancer patients with perimenopausal syndrome. Methods 60 breast cancer patients who matched the criteria were randomly divived into treatment group and control group. Treating group was treated with kidney-reinforcing and liver-regulating formula, while control group was given Gengnian An capsule. Premenopausal syndrome symptom score, the main clinical symptom score, quality of life, the level of estrogen, follicle-sti...