期刊论文

中文

湖南中医药大学学报

1674-070X

2012

32

8

14-15+21

10.3969/j.issn.1674-070X.2012.08.006.014.03

国家自然科学基金项目（81072867,307727707）； 湖南省教育厅项目（10C1034）资助；

本校为第一机构

目的 观察艾灸足阳明胃经“足三里”等穴对急性胃黏膜损伤模型大鼠HSP60、Smac表达的影响,探讨艾灸足阳明经穴抗胃黏膜损伤的保护性机制.方法 24只SD大鼠随机分为空白对照组、模型对照组、艾灸穴位组,8只/组.大鼠艾灸预处理8d,进行无水乙醇灌胃,制作急性胃黏膜损伤大鼠动物模型.用免疫组化方法检测HSP60及Smac表达.结果 与空白对照组相比,模型对照组大鼠Smac、HSP60表达均显著升高差异有统计学意义(P＜0.01);艾灸穴位组HSP60表达明显上调(P＜0.01),而Smac表达明显被抑制(P＜0.01).与模型对照组相比,艾灸穴位组Smac表达明显下降(P＜0.01),HSP60表达显著提高差异有统计学意义(P＜0.01).结论 艾灸足...

Objective To observe the effects of moxibustion pre-treatment at Zusanli and Zhongwan acupoints on expressions of heat shock protein （HSP）60 and Smac in a rat model of acute gastric mucosal lesion （AGML） and explore the underlying protective mechanisms of moxibustion for gastric mucosal lesion. Methods A total of 24 Sprague Dawley rats were divided into 3 groups, i.e. blank, model and moxibustion acupoint （n=8 each）. After an 8-day moxibustion pretreatment, the gastric lavage of anhydrous ethanol was used to establish the AGML model. The ...