期刊论文

Effects of BCG polysaccharide nucleic acid on celiac monocyte-macrophage phagocytic function in mouse

中文

湖南中医药大学学报

1674-070X

2012

32

10

8-9,26

10.3969/j.issn.1674-070X.2012.10.003.008.03

湖南省卫生厅科研项目（B2010-061）； 湖南省科技厅实验动物自主创新项目（2011TT2010）；

本校为第一机构

目的探讨卡介菌多糖核酸（BCG-PSN）对小鼠腹腔单核巨噬细胞吞噬功能的影响。方法选用BALB/c裸鼠作为免疫缺陷动物模型,将50只裸鼠随机分为BCG-PSN高、中、低剂量组,阳性对照组和裸鼠正常对照组,另选用10只正常小鼠作为空白对照组。观察BCG-PSN对小鼠的腹腔巨噬细胞吞噬功能的影响。结果 BCG-PSN高剂量组能显著提高裸鼠腹腔巨噬细胞吞噬百分率,BCG-PSN高、中、低剂量组能明显提高裸鼠腹腔巨噬细胞的吞噬指数。结论 BCG-PSN能够增强裸鼠腹腔单核巨噬细胞的吞噬功能,通过增强其表达提高裸鼠的免疫功能。

Objective To explore the effects of BCG polysaccharide nucleic acid（BCG-PSN） on celiac monocyte-macrophage phagocytic function in mouse.Methods BALB/c nude mice were used as the Immunodeficiency model,and 50 nude mice were randomly divided into five groups： high dose of BCG-PSN group,medium dose of BCG-PSN group,low dose of BCG-PSN group,positive control group and normal control group.10 normal mice were used as the blank control group additionally.Observed the effects of BCG polysaccharide nucleic acid on celiac monocyte-macrophage phagocyt...