期刊论文

Effects of XiongMa decoction and its extracts on migrane model of low 5-HT induced by reserpine

中文

湖南中医药大学学报

1674-070X

2012

32

3

17-19

10.3969/j.issn.1674-070X.2012.03.005.017.03

湖南省教育厅科研基金资助项目（06C615） 湖南省研究生科研创新项目（CX2010B351）

本校为第一机构

目的 探讨芎麻汤及其提取物对利血平所致低5-HT型偏头痛小鼠的作用机制,初步筛选芎麻汤的有效部位.方法 采用皮下注射利血平(1 mg/kg)14 d复制偏头痛模型,观察芎麻汤及其提取物时利血平偏头痛小鼠体质量、凝血时间度血浆中5-HT、NO含量的影响.结果 芎麻汤、芎麻汤正丁醇提取物组能增加偏头痛小鼠的体质量,调节5-HT的过度降低:芎麻汤、芎麻汤正丁醇提取物、芎麻汤乙酸乙酯提取物组能延长偏头痛小鼠的凝血时间,提高血浆中NO的含量,与模型组比较,差异具有统计学意义(P＜0.01).结论 芎麻汤及其乙酸乙酯提取物、正丁醇提取物具有治疗利血平所致小鼠偏头痛的作用.

Objective To study the role of Xiongma decoction and its extracts on the migrane model mouse of low 5-HT by reserpine,and screen the effective parts of XiongMa decoction preliminarily.Methods The migraine mouse model was reproduced by subcutaneous injection reserpine in a dose of 1 mg/kg once every day and lasted for 14 days.The effects of XiongMa decoction and its extracts on weight,coagulation time and 5-HT and NO content were observed.Results Compared with the modeling group,Xiongma decoction and its Butanol extract could increase mouse weig...