期刊论文

中文

湖南中医药大学学报

1674-070X

2013

33

11

24-27

10.3969/j.issn.1674-070X.2013.11.007.024.04

13JJ3096:湖南省自然科学基金 2010FJ4091:湖南省科技厅科技一般项目 11K046:湖南省高等学校创新平台开放基金 K1106040-31:长沙市科技局项目

本校为第一机构

目的 观察六味地黄汤对2 型糖尿病大鼠空腹血糖及足跖汗腺分泌的影响.方法 大鼠适应性喂养1 周后随机分为空白组和造模组,造模组大鼠高糖高脂饲料喂养联合小剂量链脲佐菌素（STZ）腹腔注射建立2 型糖尿病模型,将造模成功大鼠随机分为模型组、二甲双胍组、六味地黄汤组,给药1 个月后检测各组大鼠空腹血糖（FBG）、观察其足跖汗腺组织形态的变化.结果 六味地黄汤组、二甲双胍组与模型组空腹血糖比较,差异有统计学意义（P〈0.01）;足跖汗腺上皮细胞内空泡发生率二甲双胍组、六味地黄组与模型组比较,差异有统计学意义（P〈0.01）.结论 六味地黄汤可以改善2 型糖尿病大鼠足跖汗腺分泌增多的症状.

Objective To observe the effects of Liuwei Dihuang Decoction on fasting blood glucose（FBG） and plantar sweat gland of type 2 diabetic rats. Methods All rats were random- ly divided into control group and model group. The type 2 diabetic model was established by feed- ing high sugar and fat diet combined with intraperitoneM injection of streptozotocin（STZ）. Then these type 2 diabetic rats were randomly divided into Type 2 diabete group, Metformin group, Liuwei Di- huang Decoction group. FBG levels were detected and the changes of plantar swe...