期刊论文

Early intervention effects of Yinqiao Power on the IL-6, TNF-α expression of endotoxemia rabbits

中文

湖南中医药大学学报

1674-070X

2013

33

3

20-22

10.3969/j.issn.1674-070X.2013.03.006.020.03

国家自然自然科学基金（30801473）； 湖南省自然科学基金资助项目（10JJ4017）； 国家中医药管理局方剂学重点学科资助； 湖南省中医药大学中医临床基础重点学科资助；

本校为第一机构

目的 探讨银翘散防治感染性疾病的作用及机制.方法 将18只新西兰大耳白兔随机分为空白组、模型组、银翘散组.模型组及银翘散组经耳静脉注射内毒素造模,0.5 h测1次体温,发热后银翘散组马上用银翘散灌胃,模型组及空白组灌入等量蒸馏水,2h后心脏采血,用ELISA检测白介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)的表达.结果 与模型组比较,银翘散组IL-6、TNF-α的表达明显低于模型组(P＜0.01)；与空白组比较,银翘散组IL-6、TNF-α的表达无明显差异(P＞0.05).结论 银翘散在早期可以控制内毒素血症的炎症发展,对感染性疾病具有治疗作用.

Objective To discuss the effects and mechanisms of Yinqiao Powder on the pre-vention and control of infectious diseases. Methods 18 New Zealand big ear rabbits were random- ly divided into the blank control group, model control group, Yinqiao Powder group. Model control group and Yinqiao Powder group were injected with endotoxin via ear vein and their body temperatures were measured every 0.5 hours. Once fever occurred in these rabbits, rabbits in Yinqiao Powder group were administered intragastrically with Yinqiao Powder, model group and norma...