期刊论文

Effects of Xuefu Zhuyu Decoction on fibrinolytic activities of arterial thrombosis model rats

中文

湖南中医药大学学报

1674-070X

2013

33

11

28-31

10.3969/j.issn.1674-070X.2013.11.008.028.04

湖南省自然科学基金资助（2008031）；

本校为第一机构

目的 观察血府逐瘀汤对动脉血栓模型大鼠血浆中组织型纤溶酶原激活物(t-PA)、纤溶酶原激活物抑制剂-1(PAI-1)、纤溶酶原(PLG)含量和t-PA/PAI-1 比值的影响.方法 SD 大鼠60 只,雌雄各半,随机分为空白组、模型组、阳性对照组、血府逐淤汤高、中、低剂量组,连续灌胃给药14 d,空白组和模型组予以生理盐水,用三氯化铁外敷颈总动脉复制血栓模型,观察血栓质量和测定血浆中t-PA、PAI-1、PLG 含量.结果 模型组颈总动脉有明显的血栓形成,说明造模成功;与模型组比较,药物组血栓质量均显著降低,其中血府逐瘀汤中剂量组血栓质量最轻,差异有统计学意义(P

Objective To observe the effects of Xuefu Zhuyu Decoction on the content of t- PA,PAI-1 ,PLG and the ratio of t-PA/PAI-1 in plasma of arterial thrombosis model rats. Methods 60 SD rats, half male and half female, were randomly divided into blank group, model group, posi- tive control group, XueFu ZhuYu Decoction high, medium and low dose group. The arterial throm- bosis model was replicated by external application with FeC13 at the carotid artery. Blank group and model group were irrigated with physiological saline, other rats were respectively...