期刊论文

Effects of Yixintai on ventricular remodeling and CaN, NFAT_3 protein expression of myocardial infarction rats

中文

湖南中医药大学学报

1674-070X

2013

33

7

23-25

10.3969/j.issn.1674-070X.2013.07.005.023.03

湖南省科技计划资助项目（2009JT3040）；

本校为第一机构

目的 探讨钙调神经磷酸酶(CaN)、T 细胞活化因子3(NFAT3)蛋白表达对心肌梗死后大鼠心室重构的影响及益心泰对其干预作用.方法 制备心肌梗死大鼠模型.随机分成模型组、益心泰组、开博通组、复方丹参滴丸组和假手术组.模型组和假手术组以蒸馏水等量灌胃,其余各组分别给予相应药物灌胃,用药8 周后分别检测心室质量指数及CaN、NFAT3 蛋白表达情况.结果与假手术组比较,模型组左、右心室质量指数均增加(P

Objective To explore the effects of CaN and NFAT3 protein expression on ventricular remodeling in rats after myocardial infarction and the intervention influence of Yixintai pill on them.Methods Myocardial infarction rat models were prepared and randomly divided into model group,Yixintai group,Kaibotong group,the compound Danshen drop pill group and sham operation group.In addition to model group and sham operation group given with equivalently distilled water by lavage,the other groups were treated with corresponding mediations by lavage.After...