期刊论文

Synthesis of an Antioxidant Compound 3,4,4′,5-tetrahydroxystilbene

中文

湖南中医药大学学报

1674-070X

2014

34

4

17-19

10.3969/j.issn.1674-070X.2014.04.006.017.03

湖南中医药管理局科研项目（2012163）； 2013年度湖南省大学生创新性实验计划项目（174）； 湖南省药学重点学科资助； 湖南中医药大学“十二五”药物分析重点学科资助；

本校为第一机构

目的抗氧化活性化合物3,4,4',5-四羟基二苯乙烯的合成研究.方法以3,4,5-三甲氧基苯甲酸为起始原料,经过还原反应、卤代反应、Witting-Honner反应、缩合反应、脱甲基化反应五步制备3,4,4',5-四羟甲基二苯乙烯,产物经1H-NMR、MS分析确认结构.结果3,4,4 ',5-四羟基二苯乙烯总收率44.5％.结论该路线能顺利实现3,4,4',5-四羟基二苯乙烯的合成.

Objective To study the synthesis of an antioxidative compound 3,4,4′, 5-tetrahydroxystilbene. Methods 3,4,5-trimethoxybenzoic acid and anisaldehyde, the starting material, went through reduction, halogenations, Wittingn-Honner, condensation and demethylation reactions to produce the final product. The structure of the product was analyzed and identified by 1H-NMR and MS. Results The overall yield rate of 3,4,4′,5-tetrahydroxystilbene was 44.5%. Conclusion Our synthetic process can produce the...