期刊论文

中文

湖南中医药大学学报

1674-070X

2014

34

6

16-18

10.3969/j.issn.1674-070X.2014.06.006.016.03

湖南省教育厅科研基金资助项目（13C676）； 湖南省药学重点学科资助；

本校为第一机构

目的利用羟醛缩合反应合成一系列含有取代基的β-硝基苯乙烯类化合物。方法在乙酸铵-醋酸溶液中,各种不同类型的取代醛与硝基甲烷发生反应。产物通过熔点、质谱的检测。结果在100℃、乙酸铵-乙酸体系中能顺利地合成出一系列含有不同类型取代基的β-硝基苯乙烯。结论在该条件下反应温和,产率较高,没有聚合物产生且后处理简单,是一种简单可行的方法。

Objective To synthesize a variety of β-nitrostyrenes with different substituted groups by aldol reaction. Methods In the solution of acetic acid and ammonium acetate, benzaldehydes with different substitutes and nitromethane were proceeded smoothly. And the products were characterized by melting point and mass spectrum. Results The β-nitrostyrenes with different substitutes could get smoothly in acetic acid-ammonium acetate at 100 ℃. Conclusions The reaction is moderate to good yields in the standard condition. There is no polymer produced a...