The most common method for establishment of animal model of focal cerebral ischemia is the string-fastenings method for middle cerebral artery occlusion,but there are several defects for the method such as demanding technics,marked differences in model animals,high mortality.Therefore,establishing a stable,reliable,and reproducible animal model of focal cerebral ischemia has become an urgent problem.The choice of animal,anesthetic drugs and bolt lines,surgical procedures and postoperative care are discussed in this article in order to improve the success rate of ...