期刊论文

Antioxidant Study of Qiongyugao Yoghurt on Experimental Aging Model Mice

中文

湖南中医药大学学报

1674-070X

2015

35

6

9-13+73

10.3969/j.issn.1674-070X.2015.06.004

湖南中医药大学研究生科研创新项目（2013CX07）；

本校为第一机构

目的 探讨琼玉膏酸奶对D-半乳糖(D-gal)衰老模型小鼠的抗氧化作用.方法 SD小鼠分为空白组、模型组、普通酸奶组、琼玉膏酸奶组及琼玉膏组.采用D-gal建立小鼠衰老模型,各组分别灌胃30 d,观察小鼠体质量,心、脾、肝、脑指数的改变;分光光度法检测小鼠肝、心组织中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GSH-Px)活性及丙二醛(MDA)的含量变化;采用HE染色法观察肝组织和脑组织的形态结构变化,采用尼氏染色法观察海马组织的病理形态学变化.结果 与衰老模型组相比,琼玉膏酸奶组小鼠的一般情况改善;体质量,心、脾、肝、脑指数,肝、心组织中的SOD、CAT和GSH-Px活性均显著提高(P＜0.0...

Objective To investigate the antioxidant effects of Qiongyugao yoghurt on aging mice induced by D-galactose.Methods The SD mice were divided into the blank group, model group, yoghurt group, Qiongyugao yoghurt group and Qiongyugao group. The aging mice models were established by injecting D-gal and each group mice were given by gavage for30 days. The changes of body weight, and index of heart, spleen, liver and brain were observed; The activity levels of SOD, CAT,GSH-Px and the content changes of MDA in the liver and heart tissues of mice were ...