期刊论文

中文

湖南中医药大学学报

1674-070X

2015

35

3

30-33

10.3969/j.issn.1674-070X.2015.03.009.030.04

本校为第一机构

目的 研究肺复康对Lewis肺癌小鼠肿瘤生长及癌、癌旁组织中上皮-间质转化(EMT)相关因子E-钙黏蛋白(E-cadherin)、波形蛋白(Vimentin)和转化生长因子-β(TGF-β)表达的影响.方法 40只小鼠随机分为肺复康组(17.2 g生药/kg)、5-Fu组(25 mg/kg)、Lewis肺癌模型组、正常组.检测肿瘤体积、肿瘤质量以及癌、癌旁组织中E-cadherin、Vimentin和TGF-β的蛋白表达情况.结果 与模型组相比,肺复康组肿瘤体积减小(P＜0.01),肿瘤质量降低(P＜0.01);肺复康组抑瘤率为36％.与正常组比较,模型组癌及癌旁组织E-cadherin表达降低(P＜0.01),Vimentin、TGF-β表达升高(P＜0.01);与模型组癌及癌旁组织相比,肺复康组癌及...

Objective To study the Feifukang extract on the changes of growth of tumor and levels of E-cadherin,Vimentin, and TGF-β in cancerous and para-carcinoma tissues of mice with Lewis lung cancer. Methods 40 mice were randomly divided into Feifukang（17.2 g crude drug/kg）, 5-Fu（25 mg/kg）, model and normal group. The tumor volume, tumor weight, and the expressions of E-cadherin, Vimentin, and TGF-β in cancerous and para-carcinoma tissues were measured.Results Compared with model group, the tumor volume and weight in Feifukang group was significa...