期刊论文

中文

湖南中医药大学学报

1674-070X

2015

35

4

14-16

10.3969/j.issn.1674-070X.2015.04.004

湖南省教育厅资助课题（60010511）； 长沙市科技局资助课题（20258）；

本校为第一机构

目的 观察饥饿胁迫对小鼠认知功能和大脑海马区前脑啡肽原表达的影响.方法 将40只小鼠随机分为对照组和饥饿24h组(下称饥饿组),Morris水迷宫和八臂迷宫测试小鼠的认知功能.RT-PCR检测大脑海马区前脑啡肽原mRNA表达变化情况.结果 饥饿组与对照组比较,①在Morris水迷宫测试中,饥饿组潜伏期明显缩短(P＜0.05),通过原平台位置次数和穿越目标停留时间百分增加比(P＜0.05);②在八臂迷宫测试中,饥饿组参考记忆错误和工作记忆错误减少(P＜0.05);③在RT-PCR实验检测前脑啡肽原实验中,饥饿组小鼠大脑海马区前脑啡肽原表达明显降低(P＜0.05).结论 ①饥饿胁迫可增强小鼠的认知功能;②饥饿胁迫通过降低小鼠大...

Objective To observe the effect~ of hunger stress on cognition and the expression of proenkephalin in hippocampus of mice. Methods 40 mice were randomly divided into the control group and huger for 24 h group （huger group）. The cognitive function of mice was examined by Morris water maze and the 8-arm radial maze test. The mRNA levels of PENK in hippocampus were detected by RT-PCR. Results Compared with the control group, （1） The mean time of escape latencies in hunger group was decreased significantly by Morris water maze test （P〈0.05）;...