期刊论文

中文

湖南中医药大学学报

1674-070X

2015

35

8

31-34

10.3969/j.issn.1674-070X.2015.08.009

本校为第一机构

目的 探讨心痛泰颗粒对大鼠抗急性心肌缺血的保护作用的研究.方法 将大鼠随机分成6组,除假手术组10只外,余大鼠予以结扎大鼠冠状动脉左前降支造成大鼠急性心肌缺血损伤模型,成模大鼠随机分为模型组、心痛泰高、中、低剂量组及麝香保心丸组.分别给以蒸馏水、心痛泰低、中、高剂量及麝香保心丸进行灌胃2周后,观察3个时间点模型动物心电图S-T段变化;采用ELISA法检测血清肌酸激酶(CK)、乳酸脱氢酶(LDH)、丙二醛(MDA)和超氧化物歧化酶(SOD)含量;采用TTC染色测定心肌梗死面积;采用HE染色法观察心肌坏死组织病理变化.结果 与假手术组比较,模型组大鼠心电图S-T段抬高明显(P＜0.01)提示模型复制成功,模型...

Objective To investigate the protective effect of Xintaitong granule on the rats with acute myocardial ischemia.Methods The rats were randomly divided into six groups. Except for the10 rats in sham-operation group, the other rats were ligaturedleft anterior of coronary artery to establish the rat models of acute myocardial ischemia. The model rats were randomly divided into the model group, high-, medium-and low-dose of Xintongtai groups, and Shexiang Baoxin pill group,which were treatedseparately with distilled water, low-dose, medium-dose and...