期刊论文

中文

湖南中医药大学学报

1674-070X

2015

35

10

18-21+26

10.3969/j.issn.1674-070X.2015.10.006

2012sk3132:湖南省科技厅科技项目 2013sk3078:湖南省科技厅科技项目

本校为第一机构

目的 分析愈痫灵方对海马磷酸化环磷腺苷应答元件结合蛋白(CREB)、钙调蛋白依赖性蛋白激酶Ⅳ (CaMK Ⅳ)的关系和表达变化,探讨愈痫灵方改善戊四氮(PTZ)致痫鼠认知功能障碍的影响.方法 取健康雄性SD大鼠120只,从中随机选取10只作为正常对照组,其余大鼠用戊四氮造模,将符合模型标准的大鼠随机抽取60只分为愈痫灵组、拉莫三嗪组、丙戊酸钠组和模型组,每组15只.灌胃后用水迷宫实验测试大鼠的学习记忆能力,采用免疫组织化学方法检测p-CREB、CaMK Ⅳ在海马体CA1区的表达变化.结果 各组大鼠水迷宫实验潜伏期和总路程的学习记忆成绩比较有显著统计学意义(P＜0.001):模型组与正常组比较,差异有显著统计学...

Objective To analyse the Yuxianling Decoction on the hippocampus＇ p-CREB and CaMK Ⅳ association and their expression change. To discuss the impacts of Yu Xian Ling Decoction on improving cognitive dysfunction of epilepsy rats caused by pentylenetetrazole（PTZ）. Methods 10 rats as the normal control group were randomly selected from120 healthy male SD rats, the rest of the rats were molding with PTZ. Conform to the model standards, the 60 rats were randomly divided into the Yuxianling（YXL） group, lamotrigine（LTG） group, valproate group an...