期刊论文

中文

湖南中医药大学学报

1674-070X

2015

35

6

1-3

10.3969/j.issn.1674-070X.2015.06.001

国家自然科学基金面上资助项目（81473737）； 湖南省教育厅科研基金重点资助项目（13A072）；

本校为第一机构

目的 观察双丹明目胶囊对糖尿病视网膜病变(diabetic retinopathy,DR)大鼠视网膜血管内皮生长因子(vascular endothelial growth factor,VEGF)和血管内皮生长因子受体(vascular endothelial growth factor receptor,VFGFR)蛋白表达的影响.方法 将40只SD大鼠随机分为正常组10只,模型组30只.采用尾静脉注射链脲佐菌素(STZ)法建立DR大鼠模型,再随机分为模型对照组、双丹明目组、阳性对照组,每组10只.各组大鼠分别连续给药8周后用蛋白质印迹法(Western Blot)检测视网膜组织VEGF和VEGFR表达.结果 (1)与正常组相比,模型对照组VEGF和VEGFR蛋白表达量升高(P＜0.01);(2)与模型对照组相比,双丹明目组和阳性...

Objective To observe the effects of Shuangdan Mingmu Capsule on the expression of retinal VEGF and VEGFR protein activity in rats with diabetic retinopathy（DR）. Methods 40 SD rats were randomly divided into the normal group and model group, 10 rats and 30 rats, respectively. The DR model rats were induced by intravenous injection of STZ. Then the model rats were randomly divided into the model control group, Shuangdan Mingmu group, and positive control group. The effects of Shuangdan Mingmu Capsule on the expression of rat retinal VEGF and VE...