Objective To investigate the effect of Xuanyunding Granules on the expression of Bax, Bcl-2 and BDNF in PCIV model rabbits with the syndrome of Qi deficiency and blood stasis (QDBS). Methods The PCIV model rabbits with QDBS were prepared,Sibelium as the control of Western medicine and Xuanyunning as the control of Chinese medicine. The expression of Bax, Bcl-2 and BDNF was tested by immuohistochemisty. Results After the modeling, the contents of Bcl-2 and BDNF were lower obviously, and the expression of Bax was higher, the difference has statistical significance (P