期刊论文

Effects of Yuxianling Decoction on TLR4, NF-kB P65, TNF-α Expressions in Brain Hippocampal CA3 Region of Epileptic Rats Induced by PTZ

中文

湖南中医药大学学报

1674-070X

2016

36

1

33-36,40

10.3969/j.issn.1674-070X.2016.01.007

湖南省自然科学基金项目（14JJ2111）；

本校为第一机构

目的 探讨愈痫灵方对痫性大鼠脑组织海马区炎性反应因子表达的影响.方法 取健康雄性SD大鼠120只,从中随机选取10只作为正常对照组,10只作为假手术组,腹腔注射生理盐水;其余大鼠用戊四氮造模,将符合模型标准的大鼠随机分为愈痫灵组、丙戊酸钠组和模型组,每组10只.灌胃后采用免疫组织化学方法检测TLR4、NF-kB P65和TNF-α在海马CA3区的表达变化.结果 与正常组、假手术组比,模型组、愈痫灵方组、丙戊酸钠组均上调TLR4、NF-kB P65和TNF-α在脑组织海马CA3区的表达(P

Objective To investigate the effect of Yuxianling Decoction on the rats' brain tissue inflammatory factor expression. Methods 120 healthy male SD rats were selected, 10 rats were randomly chosen as a normal control group, 10 rats as the sham-operation group, with normal saline injected in the belly. The other rats were treated with Corazol, and divided the rats that met the standard into Yuxianling group, sodium valproate group, and model group, with 10 rats in each group. The expression of TLR4, NF-kB P65 and TNF-α in brain hippocampal CA3 re...