The mechanism and clinical treatment of intestinal endotoxemia induced the secondary liver injury were discussed by using the liver and spleen theory, which explain the inner connection between traditional Chinese medicine and Western medicine. We hold the view that the relation with the secondary liver injury induced by intestinal endotoxemia. The modern biological basis of the liver and spleen theory reflected of medical concepts: enterohepatic circulation of bile acid, interdependence of intestinal and immune function, IBF injury with vicious circl...