期刊论文

中文

湖南中医药大学学报

1674-070X

2016

36

10

76-81

10.3969/j.issn.1674-070X.2016.10.020

湖南省教育厅重点科研课题（11A084）； 湖南省科学技术厅科技计划一般项目（2012SK3132）；

本校为第一机构

目的：探讨穴位埋药线对难治性癫痫大鼠癫痫样波的发放及大脑海马和皮质中多药耐药相关蛋白 MRP1、P-gp表达的影响。方法（1）造模：大鼠海马区注射红藻氨酸（KA），经过点燃和再次亚惊厥剂量点燃造模，且脑电图检测有癫痫样波发放者筛选为造模成功耐药难治性癫痫模型鼠。（2）分组与处理：普通线组（PTX组）与药线组（YX组），先埋一侧穴位，间隔15 d后埋对侧穴位。拉莫三嗪组（LTG组）按照人用拉莫三嗪剂量换算灌胃大鼠，每日2次；空白对照组（Normal组）和模型组（Model组）给予灌胃同等体积的蒸馏水，均灌胃30 d。（3）采用VEEG-1518K型数字化视频脑电监测分析系统检测脑波基本节律的波幅与...

〔Abstract〕 Objective To discussion the acupoint embedding therapy on epileptiform wave of intractable epilepsy rats and the multidrug resistance protein 1 (MRP1)、 P-gp protein in hippocampus and temporal cortex. Methods (1) Making models:The rats were injected with kainic acid (KA) in hippocampus region, which kinded and rekinded of sub-convulsant dose to making model. The rats with EEG epileptiform wave are screened as successful modeling refractory epilepsy rats. (2) Grouping and treatment: Buried ordinary wire line group (PTX group) and t...