期刊论文

Effects of Yu Xian Ling Decoction on the Expressions of Multiple Drug Resistant Related Proteins MRP_1, P-gp, LAP MCP-1 in Refractory Epileptic Rats Induced by KA

中文

湖南中医药大学学报

1674-070X

2016

36

10

31-34

10.3969/j.issn.1674-070X.2016.10.008

湖南省教育厅重点科研课题（11A084）； 湖南省科学技术厅科技计划一般项目（2012SK3132）；

本校为第一机构

目的探讨＂愈痫灵＂方对红藻氨酸（KA）致痫难治性癫痫模型大鼠海马及颞叶皮质区多药耐药相关蛋白1（MRP1）、P糖蛋白（P-gp）、层黏连蛋白（LAP）以及单核细胞趋化蛋白1（MCP-1）表达的影响。方法 （1）造模：在脑立体定位仪引导下,海马区微量进样器注入KA1.0μL（即1.0μg）点燃发作,选取发作行为级别在Racines标准Ⅳ级以上者,以丙戊酸钠及卡马西平灌胃干预14 d后,再次以亚惊厥剂量KA0.5μL复燃,筛选再次发作级别在Ⅳ级以上或持续状态大鼠,且脑电图检测有癫痫样波放电者为造模成功的耐药难治性癫痫模型鼠。（2）分组与处理：造模成功鼠随机分为愈痫灵方干预组、拉莫三嗪对照组、模型组,另设假...

〔Abstract〕 Objective To investigate the effects of YuXianLing Decoction (YXLD) on the expressions of multi-drug resistance related protein 1 (MRP1), P-glycoprotein(P-gp), layer ankylosis protein(LAP) and Monocyte chemo attractant protein-1 (MCP-1) in hippocampus and temporal lobe cortex of the refractory epileptic rats induced by kaicic acid (KA). Methods (1) Rats models: Hippocampus located by brain stereotactic apparatus according to Paxions Watras map was micro injected 1.0 μL KA to kindle seizures. The rats with above seizure behavior su...