期刊论文

中文

湖南中医药大学学报

1674-070X

2016

36

3

27-29

10.3969/j.issn.1674-070X.2016.03.008

2013年湖南省教育厅资助研究生创新课题（CX2013B337）； 湖南省教育厅药学特色专业资助；

本校为第一机构

目的 合成6个苯甲酰胺类磷酸二酯酶-4抑制剂.方法 以异香兰素为原料,经过成醚反应、氧化反应、Schotten-Baumann反应等制备目标化合物.结果 成功制备了6个目标化合物:Benzoic acid,4-[[3-(isobutoxy)-4-methoxybenzoyl]amino](T1),Benzamide,4-[[3-(isobutoxy)-4-methoxybenzoyl]amino] (T2),Benzamide,4-(isobutoxy)-3-methoxy-N-[4-[[(1-methylethyl)amino]sulfonyl]phenyl] (T3),Benzoicacid,4-[[3-(cyclopentyloxy)-4-methoxybenzoyl]amino] (T4),Benzamide,4-[[3-(cyclopentyloxy)-4-methoxybenzoyl]amino] (T5),Benzamide,4-(cyclopentyloxy)-3-methoxy-N-[4-[[(1-methylethyl)amino]sulf...

Objective To synthesize 6 phosphodiesterase-4 inhibitors of benzamide derivatives. Methods Isovanillin as the starting material, compounds was synthesized by etherification, oxidation reaction and Schotten-Baumann reaction. Results6 target compounds were synthesized. Benzoic acid,4-[[3-（isobutoxy）-4-methoxybenzoyl]amino]（T1）, Benzamide,4-[[3-（isobutoxy）-4-methoxybenzoyl]amino]（T2）, Benzamide,4-（isobutoxy）-3-methoxy-N-[4-[[（1-methylethyl）amino]sulfonyl]phenyl]（T3）, Benzoicacid, 4-[[3-（cyclopentyloxy）-4-methoxybenzoyl]amino]（T4）...