期刊论文

中文

湖南中医药大学学报

1674-070X

2016

36

1

15-18

10.3969/j.issn.1674-070X.2016.01.003

81373641:国家自然科学基金 2011sk3104:湖南省科技厅项目 K1301014-31:长沙市科技局项目 2012sk3138:湖南省科技计划

本校为第一机构

目的 探讨知柏地黄汤对解脲支原体(Ureaplasma urealyticum,UU)感染大鼠精液质量、生精细胞凋亡及凋亡因子Cyt-c、AIF表达的影响.方法 从60 只雄性SD 大鼠中随机抽取45 只,经膀胱注射造成UU 感染动物模型,剩余15 只作为正常组.UU感染模型动物再随机分成模型组、阿奇霉素组(西药组)和知柏地黄汤组(中药组),于接种后第10 d予以模型组和正常组生理盐水灌胃,阿奇霉素组和知柏地黄汤治疗组分别予相应药物灌胃,连续干预21 d后处死动物,检测各组精子运动参数、生精细胞凋亡率及细胞凋亡因子细胞色素C(cytochrome c,Cyt-c)、细胞凋亡诱导因子(apoptosis inducing fac-tor,AIF)表达水平.结果 与正常组比较...

Objective To investigate the effect of Zhibai Dihuang Decoction on semen quality, spermatogenic cell apoptosis and apoptosis factors Cyt-c, AIF expression of Ureaplasma urealyticum (UU) infected rats. Methods 45 rats were randomly selected from 60 male SD rats, which were injected with UU by bladder to establish the infective animal models, and the remaining 15 rats were used as normal group. UU infection animal models were randomly divided into model group, azithromycin group (Western medicine group) and Zhibai Dihuang Decoction group (Chinese medicine group), on 10 d after inoculation, the m...