期刊论文

中文

湖南中医药大学学报

1674-070X

2017

37

4

349-352

10.3969/j.issn.1674-070X.2017.04.001

国家“十二五”科技重大专项子课题3（2013ZX10005004-003）.

本校为第一机构

目的 研究益肺通络颗粒体外抗结核、止血、止咳作用及对非特异免疫功能的影响,为其临床应用提供实验依据.方法 用人型结核分枝杆菌标准菌株（H37Rv）和临床分离的结核分枝杆菌敏感菌株和耐药菌株,接种于含有不同浓度益肺通络颗粒的培养基中,观察结核杆菌的生长情况;应用剪尾法、毛细管法测定小鼠的出血时间、凝血时间,观察益肺通络颗粒的止血作用;用氨水引咳,观察其止咳作用;通过巨噬细胞碳粒廓清试验,观察其对非特异性免疫功能（廓清指数和校正廓清指数）的影响.结果 益肺通络颗粒在高浓度（0.01~0.2 g/mL）时对结核分枝杆菌有显著的抑菌作用,但随着浓度降低,其抑菌效果也显著减弱,浓度减低至0...

Objective To study the effects of Yifei Tongluo granules on anti tuberculosis and the effect on relieving cough, hemostatic and non-specific immunological function. Methods Human Mycobacterium tuberculosis H37Rv and clinical isolated Mycobacterium tuberculosis sensitive strain and drug-resistant strains were inoculated in culture medium with different concentrations of Yifei Tongluo granules, separately. Growing states of Mycobacterium tuberculosis were observed. The bleeding time was measured by tail breaking test in mice and the coagulation t...