期刊论文

中文

湖南中医药大学学报

1674-070X

2017

37

11

1192-1195

10.3969/j.issn.1674-070X.2017.11.006

81303003:国家自然科学基金 81403427:国家自然科学基金

本校为第一机构

目的 观察护卵汤对慢性应激超排卵小鼠卵巢转化生长因子-β1(transforming growth factor beta 1,TGF-β1)、信号蛋白P-Smad3及卵泡刺激素受体(follicle-stimulating hormone receptor,FSHR)mRNA表达的影响.方法 建立慢性应激小鼠模型,造模成功后,随机分为模型组、护卵汤组和生长激素组,另设正常组.在超排卵第3天和注射绒毛膜促性腺激素(human chorionic gonadotropin,HCG)24 h后,检测各组卵巢TGF-β1、P-Smad3及FSHR mRNA表达.结果 与模型组比较,在超排卵第3天,护卵汤组和生长激素组TGF-β1、P-Smad3及FSHR mRNA表达均显著升高(P

Objective To investigate the effects of Huluan decoction on mRNA expression of TGF-β1, P-Smad3 and FSHR in super ovulation mice with chronic stress. Methods Chronic stress mice models were established. After modeling, the mice were randomly divided into model group, Huluan decoction group, growth hormone group, and normal group (no movement limit) was also assigned. On the third day of the super ovulation and after 24 hours of injection HCG, ovaries were taken from mice of each group for mRNA analysis of TGF-β1, P-Smad3 and FSHR. Results Comp...